The cafe is the first phase of Lettuce Entertain You’s three-phase riverfront project set to open by the end of 2019.

Pizzeria Portofino opened yesterday as the first phase of Lettuce Entertain You Enterprises’ riverfront project.

The four-story, river-facing space comprising two restaurants and an event space is the latest iteration of the RPM Restaurants series by partners R.J., Jerrod and Molly Melman of Lettuce Entertain You, chef Doug Psaltis and Bill and Giuliana Rancic. Portofino joins the group’s other River North restaurants, RPM Steak and RPM Italian.

Pizzeria Portofino is open daily for lunch and dinner, serving hand-stretched pizzas, pastas, antipasti, salads, focaccia and charcoal-grilled seafood. Located on the river level, it can be accessed via the Clark Street Bridge stairs. The three-phase, $50 million upgrade to the building at 321 N. Clark St. is set to wrap up by the end of the year. Private event space RPM Events On The Water is expected to open in September, and seafood-focused RPM On The Water sometime in the winter.

Each level of the space will feature outdoor terraces, and boat slips will be stationed along the waterfront outside Pizza Portofino.

The new RPM development is part of a larger project at 321 N. Clark that includes a renovation to the lobby and entrance on Clark Street. The real estate investment firm of Chicago investor and developer Larry Levy, Diversified Real Estate Capital, led a venture to purchase the 35-story tower for $340 million in 2016. The office building is currently 95 percent full, with major tenants including the American Bar Association, law firm Foley & Lardner and real estate services firm CBRE, according to real estate information company CoStar Group.